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OTCPicks.com Stocks to Watch for Thursday, March 15th ECYT, ECDC, NEOM, HMNY, SAVW, MDFI Our Stocks to Watch tomorrow include Endocyte Inc. (NASDAQ: ECYT), East Coast Diversified Corp. (OTCBB: ECDC), NeoMedia Technologies Inc. (OTCBB:
MDFI).Visit http://otcpicknews.com/emailmarketer/link.phpM940&N75&L1&F=T to register for our Stocks to Watch Newsletter and Email Stock Watch Alerts.ENDOCYTE INCORPORATED (NASDAQ: ECYT) “Up 58.33% on Wednesday” Detailed Quote:
http://otcpicknews.com/emailmarketer/link.phpM940&N75&L41&F=T Endocyte is a biopharmaceutical company developing targeted therapies for the treatment of cancer and inflammatory diseases. Endocyte uses its proprietary technology to create novel SMDCs and companion imaging diagnostics for personalized targeted therapies. The company`s SMDCs actively target receptors that are over-expressed on diseased cells, relative to healthy cells. This targeted approach is designed to enable the treatment of patients with highly active drugs at greater doses, delivered more frequently, and over longer periods of time than would be possible with the untargeted drug alone. The companion imaging diagnostics are designed to identify patients whose disease over-expresses the target of the therapy and who are therefore more likely to benefit from treatment.ECYT News:MARCH 13 – Endocyte to Submit EU Conditional Marketing Authorization Applications for EC145 and EC20– Expects to File Third Quarter of 2012 – EC145 and EC20 Granted Orphan Drug Status by European Commission – Updated Overall Survival Data Improved Compared to Interim AnalysisEndocyte, Inc. (NASDAQ: ECYT), a biopharmaceutical company developing targeted small molecule drug conjugates (SMDCs) and companion imaging diagnostics for personalized therapy, announced that, per discussions with EU health authorities, the Company will submit EU conditional marketing authorization applications (MAA) for EC145 and EC20 for treatment of patients with folate-receptor positive platinum resistant ovarian cancer.
The therapeutic, EC145, and the diagnostic imaging agent, EC20, have also both been granted orphan drug status by the European Commission.”After discussions with EU health authorities about Phase 3 trial plans and updated clinical data, including an updated overall survival analysis, we are pleased to move forward with these applications,” said Ron Ellis, Endocyte`s president and chief executive officer. “Targeting patients with a high unmet medical need is a prerequisite to pursuing this regulatory path and, by any measure, these patients fit that definition.”Endocyte plans to file two marketing authorization applications, one application for EC145 and another for EC20, in the third quarter of 2012.
This will ensure that the Phase 3 PROCEED trial enrollment is well underway. Per agreement with the EU regulators, if conditional marketing authorization is granted, data from the PROCEED trial would be submitted following authorization and PROCEED would serve as the confirmatory trial to support conversion to regular marketing authorization for EC145 and EC20.The marketing authorization applications will be supported by four clinical studies: a Phase 1 study in solid tumors, two single-agent, single-arm Phase 2 studies in ovarian cancer and non small cell lung cancer, and the PRECEDENT trial, a randomized study in platinum-resistant ovarian cancer. The results of the PRECEDENT trial demonstrated a statistically significant delay in disease progression or death in the overall population, with the largest improvement observed in the FR(++) patient population, those with all tumors positive for the folate receptor.
Women with FR(++) platinum resistant ovarian cancer who received EC145-based therapy experienced a 62 percent decrease in their risk of progression [HR 0.381, p= 0.018] compared to women receiving chemotherapy alone. Median progression free survival (PFS; the time without disease progressing) in the EC145 based treatment arm was 5.5 months compared to 1.5 months of women who received chemotherapy alone. Tumor shrinkage (overall response rate) was observed in 17.3 percent of women receiving the EC145-based therapy compared to 6.7 percent in patients treated with chemotherapy alone.In addition, Endocyte today announced updated overall survival data from the PRECEDENT trial, which show improvement compared to the results announced in December 2011. Overall survival was a secondary endpoint in the PRECEDENT trial, but it was underpowered to demonstrate a definitive result in this endpoint. In particular, the overall survival hazard ratio for the FR(++) patient group was 1.097. Adjusting for prognostic imbalances between the study arms, the adjusted hazard ratio of 0.481 reflects a 52 percent reduction in the risk of death. Overall survival statistics in the intent-to-treat population were also slightly improved compared to those announced in December and those data will be presented at an upcoming medical conference.”Patients with platinum-resistant ovarian cancer represent a high unmet medical need, and the presence of the folate receptor is associated with more rapid disease progression and shorter life expectancy,” said Ignace B.
Vergote, M.D., Ph.D., from University Hospital Leuven, in Belgium. “Because EC145 targets the folate receptor, these patients also have the potential to receive the greatest improvement over standard therapy. Being able to use EC20 to select patients who will most likely respond to the treatment will benefit both patients and doctors and is an important step towards implementing personalized medicine.”ABOUT EC145EC145 is a conjugate of the vitamin folate and a super-potent vinca alkaloid. Folate is required for cell division and rapidly dividing cancer cells often over-express folate receptors in order to capture enough folate to support cell division. By attaching a chemotherapy drug to folate through proprietary chemistry, EC145 targets cancer cells while avoiding most normal cells. This targeted approach is designed to provide treatment with super-potent drugs while lowering toxicity compared to standard chemotherapy.ABOUT EC20EC20 is a folate-targeted molecular imaging agent that is being developed as a non-invasive method to identify tumors that over-express folate receptors. These tumors are the molecular target of Endocyte`s folate-targeted therapeutic compounds such as EC145. To date, EC20 has been administered to over 500 patients.ABOUT ORPHAN DRUG DESIGNATIONEMA`s Orphan Medicinal Product Designation is designed to promote the development of drugs that may provide significant benefit to patients suffering from rare, life-threatening diseases. This designation will provide ten years of marketing exclusivity if the product candidate is approved for marketing for the designated orphan indication in the European Union. It also provides special incentives for sponsors, including eligibility for protocol assistance and possible exemptions or reductions in certain regulatory fees during development or at the time of application for marketing approval.EAST COAST DIVERSIFIED CORPORATION (OTCBB: ECDC) “Up 52.63% on Wednesday” Detailed Quote:
http://otcpicknews.com/emailmarketer/link.phpM940&N75&L12&F=T East Coast Diversified Corp. operates through its subsidiary, EarthSearch Communications, Inc. East Coast Diversified Corp. offers a portfolio of GPS devices, RFID interrogators, integrated GPS/RFID technologies and Tag designs. The company was founded in 2010 and is based in Atlanta, Georgia..
ECDC News:March 8 – EarthSearch Executes $1 Million Master Distributor Agreement with Asonics Live Interlink LTD KenyaEast Coast Diversified Corporation (OTCBB: ECDC), through its subsidiary EarthSearch Communications, Inc., announces the execution of Master Distributor agreement with Asonics Live Interlink Kenya for $350,000 in equipment and services purchased each year under the three year licensing agreement.The agreement would allow Asonics to be our exclusive representative in Kenya. Other partners in the market will now source products and support locally from Asonics which will be able to secure its own local distributors and partners to offer a variety of logistics solution provided by EarthSearch. EarthSearch technology provides complex logistics solution through its LogiBoxx device, the GATIS platform for monitoring fixed assets and cargo in transit. Solutions provided by EarthSearch includes Oil Tanker monitoring, Workforce management, Tool tracking, Electronic locks for cargo, Warehouse management and access control solutions using EarthSearch proprietary wireless communication between GPS and RFID.”We have been working to establish strong presence in this region for some time now. It is a vibrant and fast growing market with significant need for cargo and asset security using advanced logistics application. I am looking forward to working with Thaddeus, Joyce and Jeff and all the other executives at Asonics,” said Kayode Aladesuyi, CEO of ECDCAsonics has been testing and piloting the EarthSearch LogiBoxx device and RFID solutions over the last several months and recently committed to become a master distributor with minimum annual commitment allocated for the Kenya market. Asonics will also be able to sell on a non exclusive basis to other markets in the region.”There is a significant need for EarthSearch technology and the solutions it provides in our country as well as in other markets in the region, the movement of cargo between countries in east Africa is now more vital than ever before. The recent launching of the Lamu port by Kenyan government which will link it with Ethiopia and Sudan in the effort to harness trade among African countries is a testament to the need for this solution,” said Mr Thaddeus Mailumunguti, CEO Asonics Live Interlink.NEOMEDIA TECHNOLOGIES INCORPORATED (OTCBB: NEOM) “Up 35.64% on Wednesday” Detailed Quote:
http://otcpicknews.com/emailmarketer/link.phpM940&N75&L7&F=T NeoMedia Technologies, Inc. is the global leader in mobile barcode scanning solutions. The company`s technology allows mobile devices with cameras to read 1D and 2D barcodes and provide “one click” access to mobile content. Combining this technology with advanced analytics and reporting capabilities revolutionizes the way advertisers market to mobile consumers. NeoMedia provides the infrastructure to make 2D camera barcode scanning and its associated commerce easy, universal, and reliable — worldwide.NEOM News:March 8 – NeoMedia Launches Upgraded NeoReaderLeading barcode scanning application now updated with direct consumption features and other improvements on all platformsNeoMedia Technologies, Inc. (OTCBB: NEOM), the pioneer in global mobile barcode management solutions, today announced the launch of the updated NeoReader® barcode-scanning software applications for Apple iOS, Android, BlackBerry, Symbian and Windows Phone 7 users. The upgraded apps are available now from the Apple App Store™, Android MarketTM / Google PlayTM, BlackBerry App World™, Nokia Store and Windows® Marketplace for users to transform their devices into barcode scanners and seamlessly connect to mobile content.NeoReader bridges the gap between traditional and digital media, allowing all users with camera phones to scan both 2D and 1D code types in order to access specific web content, real-time product or service information, download content, or complete a mobile commerce transaction with one click.
Users no longer need to type in long URLs, scroll through long lists of search results or navigate cumbersome mobile phone menus.Some of the new features that will enable users to enjoy the value and convenience of a rich and relevant interactive experience, wherever they encounter a mobile barcode, are:* Ability to send email, SMS and make phone calls directly by scanning appropriate codes * Redesigned user interfaces for simpler and improved navigation * Optimized graphics performance in viewfinder mode as well as enhanced autofocus and snapshot support * Faster 1D and 2D barcode scanning * New ‘copy to clipboard’ functionality for scanned codesConsumers can easily download the NeoReader software to their phone by going to get.neoreader.com on their mobile browser or accessing their appropriate app store. HELIOS & MATHESON INFORMATION TECHNOLOGY (NASDAQ: HMNY) “Up 62.46% on Wednesday” Detailed Quote:
http://otcpicknews.com/emailmarketer/link.phpM940&N75&L27&F=T Helios and Matheson Information Technology Inc. provides information technology services and solutions to various companies and organizations.
It offers application value management, application development, integration, independent validation, infrastructure, and information management services to banking, financial services, insurance, pharmaceutical, and manufacturing/automotive industries. The company was formerly known as Helios and Matheson North America Inc. and changed its name to Helios and Matheson Information Technology Inc. on May 2, 2011.
Helios and Matheson Information Technology Inc. was founded in 1982 and is headquartered in New York, New York. HMNY News:March 12 – Helios and Matheson Renews Contract With Pharma Major; Celebrates a 20-Year RelationshipHelios and Matheson Information Technology Inc. (NASDAQ: HMNY) (the “Company”), a 30 year old IT services organization focused on banking, financial services, insurance and healthcare sectors, has renewed its Master Services Agreement for a further period of 2 years with a pharmaceutical and healthcare giant. This agreement facilitates continued provision of project services to this Fortune 100 Company who has been a client of Helios and Matheson for over 20 years.SAVWATT USA INCORPORATED (OTCBB: SAVW) “Up 100.00% on Wednesday” Detailed Quote:
http://otcpicknews.com/emailmarketer/link.phpM940&N75&L92&F=T Fast becoming the market leader in LED lighting, SavWatt focuses on developing innovative, energy-efficient and cost-effective LED lighting solutions. By delivering value added, application-specific LED lighting systems, we can significantly reduce energy costs and minimize our carbon footprint world-wide. SavWatt is leading the LED lighting revolution and setting the stage to obsolete the incandescent light bulb. SavWatt`s product families include LED fixtures, bulbs, street lights, and parking lights. SAVW News:No recent news for SavWatt USA, Inc. (OTCBB: SAVW).MEDEFILE INTERNATIONAL INCORPORATED (OTCBB: MDFI) “Up 14.29% on Wednesday” Detailed Quote:
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